Complement Components in Asthma

Original Text: Complement Components in Asthma

Objective. To assess the serum levels of complement factors C3 and C4 in Egyptian asthmatic children.

Methods. This case-controlled study comprised of 60 Egyptian children with the diagnosis of bronchial asthma (not in acute
attack) and 60 age and sex-matched healthy controls. All candidates were subjected to a thorough clinical study, complete
blood counts, absolute eosinophil count and serum complements (C3 , C4).

Results. Serum C3 was significantly higher in asthmatics when compared to controls (140.60 ± 38.80 mg /dl vs 107.70 ± 45.00
mg/dl respectively, (p = 0.01). However, differences in serum C4 levels were not significant (41.30 ± 48.80 mg/dl vs 44.60 ±
39.70 mg/dl respectively, p = 0.69). There was a significant positive correlation between severity of asthma and serum C3
(p = 0.02) but not with serum C4.

Conclusions. Serum levels of C3- but not C4 - are elevated in children with stable asthma, with a positive correlation between
serum C3 and severity of asthma. (Indian J Pediatr 2010; 77 (7):771-773) E-mail:maf939@hotmail.com

Key words: Asthma; Children; Complement

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Revised Text:

Objective: To assess the serum levels of complement factors, C3 and C4, in Egyptian asthmatic children.

Methods: This case-controlled study, comprised of 60 Egyptian children with the diagnosis of bronchial asthma (not in acute attack), and 60 age and sex-matched healthy controls. All candidates were subjected to a thorough clinical study, complete blood counts, absolute eosinophil count, and serum complements (C3 , C4).

Results: Serum C3 was significantly higher in asthmatics, when compared to controls (140.60 ± 38.80 mg /dl vs 107.70 ± 45.00 mg/dl respectively, (p = 0.01). However, differences in serum C4 levels were not significant (41.30 ± 48.80 mg/dl vs 44.60 ± 39.70 mg/dl respectively, p = 0.69). There was a significant positive correlation between severity of asthma and serum C3 (p = 0.02) but not with serum C4.

Conclusions: Serum levels of C3, but not C4, are elevated in children with stable asthma, with a positive correlation between serum C3 and severity of asthma. (Indian J Pediatr 2010; 77 (7):771-773) E-mail:maf939@hotmail.com

Key words: Asthma; Children; Complement

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